Discovery of novel ansamycins possessing potent inhibitory activity in a cell-based oncostatin M signalling assay.

نویسندگان

  • P Stead
  • S Latif
  • A P Blackaby
  • P J Sidebottom
  • A Deakin
  • N L Taylor
  • P Life
  • J Spaull
  • F Burrell
  • R Jones
  • J Lewis
  • I Davidson
  • T Mander
چکیده

We describe the isolation and characterisation of novel non-benzoquinone ansamycin metabolites related to geldanamycin from a culture of Streptomyces sp. S6699. The compounds possess potent inhibitory activity in a cell-based assay measuring inhibition of oncostatin M signalling in a reporter cell line utilising a secreted placental alkaline phosphatase (sPAP) readout. In this paper we report the isolation and structure elucidation of the compounds and describe some of their biological properties.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 53 7  شماره 

صفحات  -

تاریخ انتشار 2000